chemReactor GR / CR


Multipurpose glass pilot reactor and pilot plant


chemreactor - 15 - 250 liters pilot plant & kilo lab pharma glass reactor
chemReactor CR, 15 liter

Glass / glass lined reactor: 15 / 30 / 60 / 100 / 160 / 250 liter
Pressure: -1.0 (FV) to +0.5 bar
Temperature: -60°C (-90°C) to +200°C
Material: Borosilicate glass 3.3 / glass lined steel / PTFE / PFA / Tantalum

  • Other setups are available.

Performance and reliability are key issues in the explosion proof design of Büchi glass reaction systems: The inert materials allow safe processing in a inert atmosphere of a wide range of solvents and acids in a completely sealed glass reaction system under full vacuum. Multiple chemical reaction steps are performed safely in the same setup. Processes can be easily improved by visually observing the reaction through the glass.

The GR / CR type chemReactor is a multipurpose pilot reactor system for chemical process development, scale-up, process simulation and kilo-scale cGMP  production in batch and semi-batch operation.

We offer complete solutions for chemical processing including accessories like sampling devices, pH probes, rectification columns with structured packings, process monitoring and control as well as auxiliary equipment like temperature control units, nutsch filters / dryers, scrubbers or mixing vessels.

Standard package


  • Jacketed full glass / glass lined steel reactor
  • Multipurpose glass distillation overhead
  • Stainless steel frame, supporting flexible glass superstructure
  • ATEX Zone 1 (0) / CE / cGMP
  • CIP capable
  • FDA conform, highly corrosion resistant
  • Complete documentation

Standard options


  • Reactor lift for easy opening (vessel cleaning)
  • Sampling device
  • pH monitoring and control
  • Gas introduction (Nitrogen purging and active gas)
  • Vacuum / exhaust piping
  • Additional feeders / receivers
  • Solid feeding
  • Cryogenic vessel for low temperature chemistry (-90°C)
  • IQ / OQ / PQ

Reactor vessel


Glass / glass lined steel reactor - visual process observation and excellent heat transfer
  • Jacketed glass, glass lined steel vessel
  • 15 / 30 / 60 / 100 / 160 / 250 liter
  • Glass linded impeller stirrer
  • Glass lined baffle
  • Flush mounted drain valve

ATEX stirrer drive


ATEX agitator drive, dry running
  • ATEX motor and adjustable transmission
  • ATEX dry running mechanical seal
  • Glass lined impeller stirrer

Glass dome / Glass lined cover plate


Glass lined cover plate with glass cylinder for visual process observation
  • Glass cover dome (15 & 30 liter)
  • Glass lined steel cover (60 / 100 / 160 / 250 liter)
  • Fast-action closure for addition of solids
  • 7 connection nozzles

Lifting / lowering device (optional)


Reactor lift - easy operation

Lifting / lowering device

  • Easy opening/closing of the reactor vessel
  • Easy access for cleaning

Distillation glass overhead


Distillation glass overhead
  • Feed vessel for liquid addition
  • Distillation column / vapor duct with pressure gauge and bursting disc
  • Spiral condenser with vacuum / exhaust connection
  • Vertical condensers or horizontal setup (compact design)
  • Receiver vessel for collection of distillate
  • Dean stark phase separator
  • Vacuum / pressure equalization and distribution
  • Self-draining «büchiflex» glass piping

Examples


Visual observation of process
Visual observation of process
60 liter cryogenic reaction vessel on wheels
60 liter cryogenic reaction vessel on wheels
50 liter glass reactor with overhead
50 liter glass reactor with overhead
API reactor with protective glass coating
API reactor with protective glass coating
Vacuum manifold with glass valves
Vacuum manifold with glass valves
160 liter cryogenic reactor vessel
160 liter cryogenic reactor vessel
Hydraulic lift for 250 liter reactor
Hydraulic lift for 250 liter reactor
High-containment powder dosing
High-containment powder dosing

Typical applications


  • Vacuum distillation
  • Azeotropic distillation (phase separation)
  • Evaporation to any desired consistency
  • Multi-component reactions
  • Gas introduction into liquid phase
  • Extraction of multi phase mixture
  • Crystallization
  • Refluxing
  • Multiple chemical reactions liquid/liquid, liquid/solid
  • Low temperature chemistry

Download:


«büchiflex»

Büchi glass reactors are based on the modular «büchiflex» glass system. This unique flexible glass connection provides:

  • safety
  • economy
  • full tightness
  • clean processes

Büchiflex video


Flash is required!

Summing up